Channels
Help channels
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#aiuto - Italian dead?
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#help - English
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#help.it - Italian dead?
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#help.nl - Dutch dead?
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#hilfe - German dead?
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#pomoc - Polish
General IRC
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#ircnet
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#irchelp - IRC help channel - http://irchelp.org/
Special topics
There is an extensive (but incomplete) IRCnet channel list at https://www.ircnet.info/channels
If you are looking for the channel of a project, as for example found on sourceforge.net and can’t find such channel on IRCnet, try looking for #nameoftheproject on the irc://irc.freenode.net or irc://irc.oftc.net IRC servers.
There is also a big gaming community on irc://irc.quakenet.org.
Not a channel or a network, but http://irc.netsplit.de/ lists networks, servers and channels, worth a look. The same goes for http://searchirc.com (IRCnet section at http://searchirc.com/network/IRCNet)